The 50 most-cited articles in Journal watch, 2020

Single-agent therapy and combination immune checkpoint inhibitor therapy are now approved for microsatellite-instability (MSI)–high colorectal cancer

Both the National Institutes of Health and the Infectious Diseases Society of America/Society of Healthcare Epidemiology of America/Pediatric

The clinical spectrum of 2019 novel coronavirus (2019-nCoV) infection is still being defined. Now, investigators describe the characteristics of 99

Infection with SARS-CoV-2, the virus that causes COVID-19, appears to be highly contagious and is primarily spread by droplets. Containment efforts

Although the predominant symptoms of COVID-19 are respiratory, gastrointestinal (GI) manifestations can occur and may be overlooked. Researchers in

Dear Readers,The 2019 novel coronavirus epidemic that has emerged from Wuhan, China, appears to have the potential to have a major health impact on a

Sponsoring Organization: American Thoracic Society (ATS)BackgroundGuidelines published in 2008 by the U.S. Public Health Service (USPHS) recommended

Transmission of respiratory pathogens from asymptomatic persons to recipients no doubt occurs in many types of infection. For example, chickenpox is

COVID-19-related school closures have affected over 1.5 billion children around the world. Concern has been raised about adverse mental health

Many patients and clinicians are aware of the recently publicized interplay between SARS-CoV-2, the coronavirus responsible for COVID-19 illness, and

During infectious disease outbreaks, healthcare workers have suffered adverse psychological reactions. To learn whether this was true of the COVID-19

Currently, there are no drugs documented to be effective to treat patients with COVID-19 arising from coronavirus SARS-CoV-2 infection. However,

Dear Readers,The 2019 novel coronavirus epidemic that has emerged from Wuhan, China, has been having a major health impact on a worldwide basis.

The COVID-19 pandemic is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which shares high amino-acid sequence homology

A coronavirus (CoV) was suspected to be the cause of the December 2019 viral pneumonia outbreak in Wuhan, China, given the epidemiologic similarities

Although the CDC lists poorly controlled HIV as a condition that may place individuals at risk for severe illness from COVID-19, until now the

Dear Readers,The 2019 novel coronavirus epidemic that has emerged from Wuhan, China, appears to have the potential to have a major health impact on a

Penicillin allergy is noted in the records of more than 10% of the U.S. population; however, most patients have either “outgrown” their allergy or

A multisystem inflammatory syndrome associated with SARS-CoV-2 infection has been defined in some children (MIS-C). Researchers now report on 27 cases

The coagulopathy associated with COVID-19 has been associated with elevated D-dimer and fibrinogen levels as well as with mild thrombocytopenia and

To accompany its newly released COVID-19 Practice Advisory, the American College of Obstetricians and Gynecologists (ACOG) has posted a rolling list of

Immunotherapy with neutralizing antibodies present in convalescent plasma (CP) proved to be effective and safe for patients with SARS (severe acute

In Lombardy, the epicenter of Italy's COVID-19 pandemic, health authorities created a network of intensive care units (ICUs) to coordinate management

Whether a course of electroconvulsive therapy (ECT) reduces the risk for suicide has not been fully resolved. To address this question, investigators

Lymphopenia is a common hematological abnormality among patients with COVID-19. In addition to respiratory failure, patients with severe illness are

In the search for an effective approach to manage COVID-19, researchers in China evaluated the administration of convalescent plasma to five critically

The coronavirus disease 19 (COVID-19) pandemic has spread rapidly around the globe with considerable morbidity and mortality. Older age and

Three teams of investigators are developing serologic tests to answer key questions about SARS-CoV-2. Guo and colleagues looked at the kinetics of

The American Cancer Society has published updated colorectal cancer (CRC) incidence data (through 2016) from populationbased cancer registries and

Coronaviruses (CoV) have recently challenged global medicine through their ability to emerge as human pathogens from zoonotic sources, as shown by

The first reports of the clinical characteristics of 2019 novel coronavirus (2019-nCoV) were recently published (NEJM JW Infect Dis Feb 2020 and Lancet

Identifying people infected with 2019 novel coronavirus (2019-nCoV) in order to isolate them will be essential to halt virus spread. Can people

Coronaviruses typically cause common cold symptoms, but two previously identified betacoronaviruses, SARS-CoV and MERS-CoV, can result in severe

The efficacy of monthly injectable long-acting cabotegravir plus rilpivirine (LA CAB+RPV) for HIV infection was recently demonstrated in the ATLAS (N

The rapid development of SARS-CoV-2 vaccines is one of the few bright spots of 2020. The lipid nanoparticle-formulated, nucleoside-modified mRNA

Ofatumumab is a subcutaneous anti-CD20 monoclonal antibody self-administered once monthly by injection. It has been approved for relapsing-remitting

Minocycline, a tetracycline antibiotic, has been shown to improve symptoms of schizophrenia and bipolar depression, ostensibly by reducing inflammatory

Previous studies in adults have associated problem gambling with traumatic brain injury (TBI), alcohol use disorder, and suicidality. To see whether

In addition to the direct effects of SARS-CoV-2, several studies have found a higher than expected incidence of thrombotic events (pulmonary embolism

Sponsoring Organization: World Brain Death Project, assisted by international professional societies including the World Federation of Intensive and

Sponsors and Authors: A multinational group of experts in the problematic use of information and communications technology (ICT), who were supported by

The New York City metropolitan area emerged as an epicenter of the COVID-19 pandemic. A recent population study showed a prevalence of SARS-CoV-2

For many patients with multiple sclerosis (MS), severe fatigue is the most disabling symptom of the illness and a common cause of absence from work.

SARS-CoV-2 virus causes severe multisystem disease beyond acute respiratory distress syndrome. The mechanism of nonpulmonary involvement seems to

As school districts nationwide contemplate reopening K–12 schools, considering the potential repercussions on COVID-19 transmission is of great

The challenges faced by grandparents and their ability to cope with the complicated circumstances of raising grandchildren are important health

Sponsoring Organization: American Academy of Pediatrics (AAP)Background and ObjectiveIn March of this year, many schools transitioned from in-person to

Because patients with severe COVID-19 often have evidence of excess inflammation, intense interest has centered on whether anti-inflammatory

Overall, the genetic sequence diversity of SARS-CoV-2 is low. However, because most vaccine and antibody therapies target the trimeric spike protein,

Confusion exists about whether to screen and treat women for subclinical hypothyroidism during pregnancy and even about what constitutes this