The 50 most-cited articles in Journal watch, 2018

Mindfulness-based cognitive therapy (MBCT) is effective for patients with remitted or current depression; preliminary work shows its promise for

Sponsoring Organization: Centers for Disease Control and Prevention (CDC)Target Audience: Primary care providers, infectious disease specialists,

Intimate partner violence (IPV) is ordinarily defined as violence or abuse that is physical, sexual, or emotional/psychological. Researchers in South

Using multiple administrative and surveillance databases, researchers have estimated the current burden and cost of gastrointestinal (GI) disease

Prior research has cast doubt on the value of endotracheal intubation of cardiac arrest patients by paramedics (NEJM JW Emerg Med Apr 2018 and JAMA

In February, the FDA approved the first blood biomarker test for diagnosis of traumatic brain injury (TBI); it measures ubiquitin C-terminal

Five large trials from the U.S., Australia, New Zealand, Canada, and the U.K. compared outcomes in extremely preterm infants (<28 weeks' gestation)

A 2013 guideline from the American Academy of Orthopaedic Surgeons recommended strongly against hyaluronic acid injections (viscosupplementation) for

Natriuretic peptides are used to ascertain the likelihood that heart failure (HF) is accounting for patients' symptoms of dyspnea. The FDA has approved

Investigators at the 2018 Gastrointestinal Cancers Symposium, held January 18–20 in San Francisco, reported key advances in GI cancer research. NEJM

Sponsoring Organization: American Academy of Pediatrics (AAP)Target Population: Medical and surgical patients aged 28 days to 18 years on critical care

Probiotics are widely used to treat symptoms of gastroenteritis, without high-quality supporting evidence. Two large, high-quality studies now provide

Racial disparities in mortality from cardiovascular disease are driven partly by disparities in hypertension. To explore clinical and social factors

Synthetic cannabinoid use is increasing (Physician's First Watch Jul 15 2016), and use of new compounds can result in clusters of patients with unique

Sponsoring Organization: Castleman Disease Collaborative NetworkBackground and ObjectiveIdiopathic multicentric Castleman disease (iMCD) is

Sponsoring Organization: U.S. Preventive Services Task Force (USPSTF)Target Audience: Women's healthcare providersBackgroundDuring the past decade,

Randomized trials have established the noninferiority of direct-acting oral anticoagulants (DOACs) compared with warfarin in patients with atrial

Administration of a uterotonic such as oxytocin helps prevent postpartum hemorrhage after vaginal delivery; however, oxytocin requires cold storage. Is

In January 2016, the model for end-stage liver disease (MELD) score was refined to take into account serum sodium level, creating the MELD-Na score.

Clinicians who order imaging studies often deal with “incidentalomas” — imaging test findings that are reported serendipitously in a patient who is

Children with vesicoureteral reflux (VUR) are often given oral antibiotic prophylaxis to prevent recurrent urinary tract infections (UTIs). Researchers

Mycoplasma genitalium was first identified in the 1980s as a cause of urogenital disease. However, little is known about its natural history,

Many patients still need or desire mastectomy as treatment for (or prophylaxis against) breast cancer, and subsequent breast reconstruction can improve

Clinical lore says that resection of a primary tumor can cause previously inapparent metastatic deposits to flare. In a mouse model of breast cancer,

One of the most common yet difficult management problems in medicine is that of patients who presents with a paroxysmal loss of consciousness. One

Sponsoring Organization: The Surviving Sepsis CampaignTarget Population: Emergency physicians and intensivistsBackground and ObjectiveSepsis “bundles”

Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines recommend stepwise therapy for patients with chronic obstructive pulmonary

Prosthesis–patient mismatch (PPM), a small surgical aortic valve orifice for a patient's size, has been associated inconsistently with mortality, and

Both migraine headaches and depression are common disorders, and they co-occur frequently. Because the triptan class of medications often is used to

Thalamic atrophy is an early imaging feature of multiple sclerosis (MS) and is thought to reflect neurodegenerative processes.To examine the evolution

In previous studies, proximal colon sessile serrated polyps (SSPs) and large hyperplastic polyps (HPs; which might have been SSPs) have been associated

Sponsoring Organization: American Psychiatric Association (APA)Target Audience: Prescribing providers in primary care, psychiatry, and

For patients who present with hip fracture, current American College of Surgeons guidelines recommend surgery within 48 hours. However, could more

Despite the increasing number of disease-modifying drugs (DMDs) available for multiple sclerosis (MS), little is known about the prevalence of

Infliximab, a monoclonal antibody against tumor necrosis factor-α, is approved for use in rheumatoid arthritis and psoriasis; it has also been used

The Platelet-Oriented Inhibition in New TIA and minor ischemic stroke (POINT) trial was published earlier this year and showed benefit with the use of

Dear Readers,This year has been marked by the insanity of the opioid epidemic, but there have been significant advances on less sensational topics. A

Autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD) commonly co-occur in the same child, or within members of the same

Resumption of menses, an important sign of recovery in adolescents with anorexia nervosa (AN), depends on the total body fat percentage. Bioelectrical

Adolescents often do not receive the 8 to 10 hours of sleep recommended by the American Academy of Pediatrics due to both late sleep-start and early

Dear Readers,This past year has seen the publication of many high-quality research studies informing the practice of gastroenterology and hepatology.

Myelin oligodendrocyte glycoprotein (MOG) autoantibody disease is a neuromyelitis optic spectrum disorder (NMOSD) whose prognosis differs from that of

Cross-sectional studies have shown increased rates of gaming disorder (GD) among young adults with attention-deficit/hyperactivity disorder (ADHD) and

Systemic autoimmune rheumatic diseases (SARDs; e.g., systemic lupus erythematosus, systemic sclerosis, Sjogren syndrome, myositis, and antineutrophil

In our annual review of the year's most important clinical research, the editors of NEJM Journal Watch try to balance relevance to general medicine and

Dear Readers,I'm happy to present the NEJM Journal Watch Women's Health Top Stories of 2018.Key obstetric studies addressed labor induction at 39

Magnetic resonance guided focused ultrasound (MRgFUS) thalamotomy is FDA approved for unilateral essential tremor treatment. One big concern has been

For nearly 20 years, clinicians have debated about whether to treat septic shock patients with corticosteroids. In 2018, two large trials added to the

Cognitive-behavioral therapy (CBT) is recommended for schizophrenia patients in British and U.S. guidelines. Although one study estimated that a third

Critical care providers continue to struggle with finding the right time to start renal replacement therapy (RRT) for intensive care unit (ICU)