About Pharos (NIH druggable targets)
The portal of the Illuminating the Druggable Genome programme. Classifies every human protein as Tclin, Tchem, Tbio or Tdark, and links it to diseases, approved drugs and active ligands, pathways and publication counts. Search by target or by disease.
Questions you can ask Pharos
Type them into Kahubi’s chat once Pharos is connected.
“Is GPR75 a druggable target? What is its development level and which diseases is it linked to?”
What comes back: The target’s development level (Tclin to Tdark), associated diseases, known ligands and publication count.
“Which understudied (Tdark) proteins are associated with Parkinson’s disease?”
What comes back: Targets with development level, family and novelty score, from Pharos’ disease associations.
Pharos MCP tools
The 3 tools the Pharos server offers to Kahubi. The assistant picks the right one for each question.
pharos_search_targetsSearch targets by name, gene symbol, UniProt id or keyword.
pharos_get_targetOne target by gene symbol or UniProt id: description, TDL, family, associated diseases with source counts, approved/active ligands, pathways, GO terms, publication count.
pharos_search_diseasesSearch diseases.
Using Pharos in Kahubi
- Hosted by Kahubi. Kahubi runs this server itself so it stays reliable enough for research use.
- Cited, checkable answers. Results are treated as retrieved material and cited with the source’s own identifiers, so you can open every record the answer relied on.
- Your files stay private. Only the search the assistant writes for your question is sent to Pharos.
More life science sources
- TogoMCP (UniProt, ChEMBL, PubChem, PDB, Reactome, NCBI)One service across 30+ life-science databases: proteins, genes, compounds, structures, pathways, variants and MeSH.
- Open Targets PlatformTarget–disease–drug associations with the evidence behind them, from EMBL-EBI.
- Protein structures (PDB, AlphaFold)Search experimental and predicted protein structures, find similar folds, track ligands and fetch annotations.
- NCBI E-utilitiesGene, ClinVar, dbSNP, Taxonomy, Nucleotide, Protein, PMC and other NCBI databases.
- GBIF (biodiversity occurrences)2.5 billion species occurrence records from museums, surveys and citizen science worldwide.
- iNaturalistCitizen-science observations with photos, research-grade identifications and places.