About Rhea (biochemical reactions)
The SIB reaction knowledgebase behind UniProt’s enzyme annotation. Search by participant, EC number or ChEBI id and get the balanced equation, the enzymes that catalyse it and the compounds involved.
Questions you can ask Rhea
Type them into Kahubi’s chat once Rhea is connected.
“Which reactions does lactate dehydrogenase catalyse, as balanced equations?”
What comes back: Rhea reactions with id, balanced equation, EC number and participant ChEBI ids.
“Which enzymatic reactions involve acetyl-CoA as a substrate?”
What comes back: Curated reactions with equations and the enzymes that catalyse them.
Rhea MCP tools
The 1 tool the Rhea server offers to Kahubi. The assistant picks the right one for each question.
rhea_search_reactionsSearch expert-curated, balanced biochemical reactions by participant, enzyme (EC number, "ec:1.1.1.1"), ChEBI id ("chebi:15377") or text.
Using Rhea in Kahubi
- Hosted by Kahubi. Kahubi runs this server itself so it stays reliable enough for research use.
- Cited, checkable answers. Results are treated as retrieved material and cited with the source’s own identifiers, so you can open every record the answer relied on.
- Your files stay private. Only the search the assistant writes for your question is sent to Rhea.
More chemistry & materials sources
- PubChemCompound identity, properties, similarity and substructure search, GHS safety data, from 119M compounds.
- ChEMBL (bioactivity)Drug-like molecules with measured bioactivities, targets and mechanisms of action, curated by EMBL-EBI.
- ChEBI (chemical ontology)Curated dictionary of chemical entities: definitions, classes, roles and synonyms.
- OPSIN (name to structure)Turns a systematic IUPAC name into a structure by rule, also for compounds no database lists.
- Crystallography Open DatabaseOver 500,000 open-access crystal structures: organic, inorganic, metal-organic and minerals.